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帕金森患者黑质体积及铁沉积的磁敏感加权成像研究 被引量：8

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摘要 帕金森病（Parkinson＇s disease，PD）是一种常见的发生在中老年人神经系统变性疾病。其病理学改变主要是黑质（sub-stantianigra，SN）-纹状体多巴胺能神经元变性、缺失。尽管这类疾病的病因及发病机制尚不明确，但一般认为与铁代谢异常有关[1]。虽然脑铁与PD病理学改变存在密切关系，但常规检查多不能发现特异性改变，近年来功能影像学被逐渐应用于PD的早期诊断及非运动症状等研究[2-3]。
作者 张慧萍 陆强彬 杨江胜 周国庆 姜岐涛 朱祖福
机构地区 东南大学医学院附属江阴医院神经内科 东南大学医学院附属江阴医院影像科
出处 《中华行为医学与脑科学杂志》 CAS CSCD 北大核心 2014年第9期827-828,共2页 Chinese Journal of Behavioral Medicine and Brain Science
基金 无锡市科技指导性计划项目（CSZ00N1252）
关键词 磁敏感加权成像 黑质 神经系统变性疾病 铁沉积 帕金森 病理学改变 体积 患者
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献12

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二级参考文献27

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共引文献35

同被引文献67

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  • 3杨明慧,周辉,赵骐.磁敏感加权成像在中枢神经系统的临床应用[J].中外健康文摘,2014,2(8):264.265.
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  • 6刘亚欧,李坤成,杨延辉,安靖,于春水,赵澄,王辉.磁敏感加权成像在颅内肿瘤成像的初步应用[J].医学影像学杂志,2008,18(1):4-7. 被引量：33
  • 7Zhang J, Zhang Y, Wang J, et al. Characterizing iron depo- sition in Parkinson' disease using susceptibility-weighted ima- ging: an in vivo MR study. Brain Res, 2010, 1330: 124-130.
  • 8Schwarz ST, Afzal M, Morgan PS, et al. The 'Swallow Tail' Appearance of the Healthy Nigrosome-A New Accurate Test of Parkinson ' s Disease : A Case-Control and Retrospec- tive Cross-Sectional MRI Study at 3T. PLoS ONE, 2014, 9 (4) : e93814.
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引证文献8

二级引证文献49

中华行为医学与脑科学杂志
2014年 第9期

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