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Wnt信号转导通路与间充质干细胞分化 被引量：2

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摘要 Wnt信号转导通路与细胞生长、分化及老化等密切相关,其异常表达或激活能引起多种疾病。Wnt信号转导通路与成骨细胞、软骨细胞及脂肪细胞生理功能密切相关,通过调控Wnt信号转导通路影响成骨细胞、软骨细胞和脂肪细胞及其前体间充质干细胞生物学行为,可作为临床治疗骨骼疾病的策略。该文就Wnt信号转导通路调控间充质干细胞向成骨细胞、软骨细胞和脂肪细胞分化研究进展作一综述。
作者 胡浩然 赵必增 周栓虎 沈龙祥
机构地区 上海交通大学附属第六人民医院骨科 美国Brigham妇女医院骨科
出处 《国际骨科学杂志》 2014年第5期325-328,共4页 International Journal of Orthopaedics
基金 国家自然科学基金(81201440)
关键词 WNT信号转导通路 成骨细胞 软骨细胞 脂肪细胞 间充质干细胞
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
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参考文献61

  • 1Huang X,McGann JC,Liu BY, et al. Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling[J]. Science, 2013, 339(6126) : 1441-1445.
  • 2Arthur A,Zannettino A,Gronthos S. The therapeutic applications of multipotential mesenchymal/ stromal stem cells in skeletal tissue repair[J]. J Cell Physiol, 2009 , 218(2):237-245.
  • 3Monroe DG, McGee-Lawrence ME, Oursler MI,et al. Update on Wnt signaling in bone cell biology and bone disease[J]. Gene, 2012 , 492(1):1-18.
  • 4Sarahrudi K,Thomas A,Albrecht C,et al. Strongly enhanced levels of sclerostin during human fracture healing[J]. J Orthop Res, 2012,30(10):1549-1555.
  • 5Zhang W, Drake MT. Potential role for therapies targeting DKK1, LRP5, and serotonin in the treatment of osteoporosis [J]. Curr Osteoporos Rep, 2012,10(1):93-100.
  • 6Bae S,Yoon Y. Anti-adipogenic activity of berberine is not mediated by the WNT/β-catenin pathway[J]. Phytother Res, 2013,27(6) :937-943.
  • 7Freise C, Trcwitzsch-Kienast W, Erben U, et al. (+)-Episesamin inhibits adipogenesis and exerts anti-inflammatory effects in 3T3-L1 (pre) adipocytes by sustained Wnt signaling, down-regulation of PPARγ and induction of iNOS[J]. J Nutr Hochem, 2013 , 24(3) :550-555.
  • 8Momose T,Kraus Y, Houliston E.A conserved function for Strabismus in establishing planar cell polarity in the ciliated ectoderm during cnidarian larval development[J]. Development, 2012, 139(23) :4374-4382.
  • 9Qiu W,Chen L, Kassem M. Activation of non- canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells[J]. Biochem Hophys Res Commun, 2011,413(1):98-104.
  • 10Taipaleenmaki H, Abdallah BM, AlEbhmash A,et al. Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations[J]. Exp Cell Res, 2011,317(6) :745-756.

同被引文献24

  • 1CHEN K Y, CHUNG C M, CHEN Y S, et al. Rat bone marrow stro- mal ceils - seeded porous ge - latin/tricalcium phosphate/oligo- meric proan - thocyanidins composite scarf old for bone repair[J]. Tissue Eng Regen Med, 2013, 7(9) : 708 -719.
  • 2GUO Y, XIAO L, SUN L, et al. Wnt/beta - catenin signaling: a promising new target for fibrosis diseases. [ J ]. Physiol Res, 2012, 61 (4) :337 -46.
  • 3HUANG H, HE X. Wnt/beta - catenin signa - ling: new ( and old) Player and new insights[J]. Curt OPin Cell Biol 2010:20 (2) :119 -125.
  • 4MONROE D G, MCGEE M E, OUR M J, et al. Update on Wnt signaling in bo - ne cell biology and bone disease [ J ]. Gene, 2012,492(1) : 1 -18.
  • 5JULLIEN N, MAUDINET A, IXLOUTRE B, et al. Downregula- tion of ErbB3 by Wnt3a contributes to wnt- induced osteoblast dif- ferentiation in mesenchymal cells [ J]. Cell Biochem, 2012, 113 (6) :2047 -2056.
  • 6SHIN Y, HUH Y H, KIM K, et al. Low -density lipoprotein re- ceptorrelated protein 5 governs Wnt - mediated osteoarthritic carti- lage destruction [ J]. Arthritis Res Ther,2014,16 ( 1 ) .
  • 7LUO S, SHI Q, ZHA Z, et al. Inactivation of Wnt/13 - catenin signaling in human adipose -derivedstemeells is necessary for chondrogeniedifferentiation and maintenance [ J ]. Biomed Pharma- eother,2013,67 (8) :819 - 24.
  • 8NALESSO G, SHERWOOD J, BERTRAND J, et al. Ramachand- ran M, De Bari C, Pitzalis C, Dellccio F. WNT -3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways [ J]. Cell Bio1,2011,193 ( 3 ) :551 - 64..
  • 9LIU S, ZHANG E, YANG M. Overexpression of Wntl 1 promotes chondrogenic differentiation of bone marrow - derived mesenchy- real stem cells in synergism with TGF - 13 [ J ]. Mol Cell Bio- chem,2014,390(1 -2) :123 -31.
  • 10GVDHORST, SMVDWERF, HFARIH, et al. Down regulation of Wnt signaling by in - creased expression of Dickkopf - 1 and - 2 is a p - rerequisite for late - stage osteoblast differentia - tion of KS483 cells[J]. J Bone Miner Res 2012; 20 (10) : 1867 - 1877.

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国际骨科学杂志
2014年 第5期

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