长春新碱不良反应影响因素的研究进展

Influence factors of vincristine＇s adverse reaction

在儿童肿瘤的治疗中，长春新碱是应用最广泛、疗效最确切的药物之一，但是长春新碱诸多的不良反应限制了其在临床中的应用。近年来研究发现，长春新碱在人种以及个体间有不同的代谢速率，与咪唑类抗真菌药等药物联合使用可能会增强其不良反应。新型给药系统的研究为降低长春新碱的不良反应，提高其生物利用度提供了新思路。

During the treatment of pediatric tumor,vincristine is one of the most widely used and most effective drugs. However,the adverse reactions have limited its clinical application. In recent years,studies have found that the metabolism of vincristine are different in different races and different individuals,and coad-ministration with certain drugs such as imidazoles antifungal drugs may enhance its adverse reaction. Researches on new drug delivery system provide a new idea for reducing the adverse reactions of vincristine and improving its bioavailability.