期刊文献+

代谢组学在肝细胞肝癌标志物中的研究进展 被引量:5

下载PDF
导出
摘要 肝细胞肝癌(HCC)发病率、死亡率高,预后极差,临床监测和早期诊断是降低其死亡率的主要方法。由于早期无症状,发现往往已是晚期,现有的肿瘤标志物尚无法满足临床的要求。代谢组学致力于研究生物体系受刺激产生的所有代谢产物的变化,它的提出为发现潜在HCC肿瘤标志物提供新思路。已有学者利用色谱、质谱、磁共振等技术平台从患者血液、尿液、粪便、组织等标本中寻找代谢产物差异,发现潜在的HCC标志物,并探讨其诊断价值。本文就近年来应用代谢组学研究HCC标志物的相关进展作一综述。
出处 《临床检验杂志》 CAS CSCD 北大核心 2014年第8期600-602,共3页 Chinese Journal of Clinical Laboratory Science
  • 相关文献

参考文献2

二级参考文献11

  • 1Lina Zhou,Quancai Wang,Peiyuan Yin,Wenbin Xing,Zeming Wu,Shili Chen,Xin Lu,Yong Zhang,Xiaohui Lin,Guowang Xu.Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases[J].Analytical and Bioanalytical Chemistry.2012(1)
  • 2Eriksson L,Johansson E,Kettaneh-Wold N et al.Multi- and Megavariate Data Analysis: Principles and Applications[].Journal of Women s Health.2001
  • 3Masuzaki R,Karp SJ,Omata M.New serum markers of hepatocellular carcinoma[].Seminars in Oncology.2012
  • 4Wu H,Xue R,Dong L,Liu T,Deng C,Zeng H, et al.Metabolomic profiling of human urine in hepatocellular carcinoma patients using gas chromatography/mass spectrometry[].Analytica Chimica Acta.2009
  • 5Y Tan,P Yin,L Tang,W Xing,Q Huang,D Cao,X Zhao,W Wang,X Lu,Z Xu,H Wang,G Xu.Metabolomics study of stepwise hepatocarcinogenesis from the model rats to patients: potential biomarkers effective for small hepatocellular carcinoma diagnosis[].Molecular and Cellular Proteomics.2012
  • 6T Soga,M Sugimoto,M Honma,M Mori,K Igarashi,K Kashikura,S Ikeda,A Hirayama,T Yamamoto,H Yoshida,M Otsuka,S Tsuji,Y Yatomi,T Sakuragawa,H Watanabe,K Nihei,T Saito,S Kawata,H Suzuki,M Tomita,M Suematsu.Serum metabolomics reveals γ-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease[].Journal of Hepatology.2011
  • 7M Scigelova,A Makarov.Coupling liquid chromatography to Orbitrap mass spectrometry[].Journal of Chromatography A.2010
  • 8Trygg J,Holmes E,Lundstedt T.Chemometrics in Metabo- nomics[].Journal of Proteome Research.2007
  • 9HG Gika,GA Theodoridis,JE Wingate,ID Wilson.Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: Application to human urine[].Journal of Proteome Research.2007
  • 10W.B. Dunn,D. Broadhurst,M. Brown,P.N. Baker,C.W. Redman,L.C. Kenny,D.B. Kell."Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system"[].Journal of Chromatography B.2008

共引文献114

同被引文献68

引证文献5

二级引证文献17

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部