药用卤化丁基胶塞中脂肪酸类物质含量的测定

Determination of Fatty Acids in Rubber Stoppers

建立了检测胶塞中脂肪酸含量的分析方法。胶塞经极低温冷冻粉碎处理后,以脂肪酸的甲酯化合物为外标,通过气相色谱法(GC)测定计算胶塞中脂肪酸含量。结果表明:该方法的加标回收率为95.72%,相对标准偏差(RSD)为4.24%。该方法专属性、准确性和重现性好。

A quantitative determination method of fatty acids in rubber stoppers was developed. Rubber stoppers were firstly frozen in ultra-low temperature, and then ground into powder. Fatty acid methyl esters were used as external standards, and fatty acids in rubber stoppers were calculated from the results measured by gas chromatographic method（GC）. The results show that the average sample-adding recovery is 95.72%, and the average relative standard deviation（RSD） is 4.24%. The method is specific, accurate and reproducible.