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帕利哌酮与齐拉西酮治疗精神分裂症有效性和安全性的Meta分析 被引量:6

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摘要 目的评价帕利哌酮与齐拉西酮治疗精神分裂症的有效性和安全性。方法检索2009年2月至2013年8月国内公开发表的帕利哌酮与齐拉西酮治疗精神分裂症的相关文献,采用Rev Man 5.0对符合条件的文献进行Meta分析。结果共有5篇文献,451例患者满足纳入标准,其中试验组226例,对照组225例。Meta分析显示:两组治疗后临床有效率差异无统计学意义;PANSS评分方面,仅在阳性症状控制方面,帕利哌酮优于齐拉西酮[为-1.48,95%为(-2.41^-0.55)],其他PANSS评分差异无统计学意义;不良反应发生率方面,仅在体质量增加方面,帕利哌酮优于齐拉西酮[为3.56,95%为(1.06~12.10)],其他不良反应差异无统计学意义。结论帕利哌酮治疗精神分裂症安全有效,仅在阳性症状方面和体质量增加方面有差异。
出处 《现代实用医学》 2014年第8期964-965,共2页 Modern Practical Medicine
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