溶栓治疗急性脑梗死对QT离散度的影响及其临床意义

Influence of thrombolytic therapy for acute cerebral infarction on QT dispersion and its clinical significance

目的探讨急性脑梗死溶栓成功患者和未溶栓患者QT离散度(QTd)的变化及其临床意义。方法选取77例急性脑梗死患者分为溶栓再通A组(41例)和未溶栓B组(36例)。分析两组患者QTd和QTcd(心率校正后的QTd)的变化以及室性心律失常的发生情况。结果A组QTd及QTcd较B组显著减小,差异有统计学意义(P<0.05);A组发生室性心律失常较B组明显减少,差异有统计学意义(P<0.05)。结论成功溶栓的急性脑梗死患者QTd及QTcd减小,其发生室性心律失常明显减少。

Objective To investigate the changes of QT dispersion（QTd）and its clinical signif-icance for patients with acute cerebral infarction after successful thrombolytic therapy and non-throm-bolytic ones.Methods Seventy-seven patients with acute cerebral infarction were divided into thrombolytic recanalization group （group A,41 cases）and non-thrombolysis group （group B,36 cases）.Between the 2 groups,the changes of QTd and QTcd（corrected QT dispersion）and the oc-currence of ventricular arrhythmia were analysed.Results Compared with group B,QTd,QTcd and the occurrence of ventricular arrhythmia in group A all decreased significantly with statistically significant differences（P〈0.05 ）.Conclusion Amongst patients with acute cerebral infarction, their QTd and QTcd both decrease and the occurrence of ventricular arrhythmia also reduces signifi-cantly after successful thrombolytic therapy.