肺癌演进与癌相关成纤维细胞代谢转变的关系及进展

Advancement of Relationship between Metabolic Alteration in Cancer-associated Fibroblasts and Tumor Progression in Lung Cancer

肺癌的演进与"肿瘤微环境"变化密切相关,癌相关成纤维细胞(cancer-associated fibroblasts,CAFs)是被癌细胞"驯化"的成纤维细胞,是肿瘤微环境的重要成员之一。CAFs还具有促进肿瘤细胞生长、侵袭和转移的特性。研究表明CAFs的物质能量代谢方式与正常的成纤维细胞有明显不同。CAFs以糖酵解生成乳酸的方式进行代谢并将乳酸供给癌细胞,即CAFs表现为"反瓦伯格效应(reverse Warburg effect)"的代谢形式以适应和促进肿瘤细胞的演进。本文针对CAFs代谢转变与肺癌演进的关系,从以下五个方面进行综述:1CAFs的特性及其代谢特点;2CAFs代谢的研究现状;3CAFs代谢方式转变可能的分子机制;4CAFs代谢方式转变与肺癌演进的关系;5CAFs代谢方式的转变与肺癌预后和治疗的关系。

Tumor microenvironment is closely related to tumor progression. Cancer-associated ifbroblasts （CAFs） are specialized ifbroblasts domesticated by cancer cells surrounding them. CAFs are one of the most important components in cancer microenvironment. CAFs extensively involved in tumor genesis, tumor invasion and metastasis. Compared to NFs, CAFs also have a different metabolism type. CAFs use glycolysis to produce lactate for cancer cells. hTat is, CAFs turn to a metabolism type named“reverse Warburg effect”to promote tumor progression. In the present study, we summarized that：（1） Characteristics and metabolic type of CAFs;（2） hTe research status of the metabolism of CAFs;（3） hTe potential mechanism of CAFs metabolism;（4） hTe relation between metabolic alteration in CAFs and lung cancer progression;（5） Relationship between CAFs metabolism and lung cancer prognosis and therapy.