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表观遗传新标志物5hmC的研究进展 被引量：4

Research Advances on The New Epigenetic Marker: 5-Hydroxymethylcytosine
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摘要 5-羟甲基胞嘧啶(5-hydroxymethylcytosine,5hmC)作为表观遗传的新标志物,已引起人们的极大兴趣.5hmC由TET家族酶催化氧化5-甲基胞嘧啶(5-methylcytosine,5mC)产生,被称为高等生物基因组DNA的"第六碱基".5hmC不仅可以影响基因组结构及功能,还在早期胚胎发育中发挥重要的作用.本文综述了5hmC的代谢通路、生物学功能、在基因组的分布及分析方法的研究进展. Recently, the new epigenetic marker, 5-hydroxymethylcytosine （5hmC） has been widely studied. 5hmC derived from the enzymatic oxidation of 5-methylcytosine （5mC） by TET（ten-eleven translocation） protein family and called as the ＂six base＂ of higher organism genomic DNA. It is found that 5hmC not only influence the structure and function ofgenome, but also play an important role during early embryonic development. This review mainly discussed the research advances of 5hmC in metabolic pathways, biological function, genome distribution and analysis methods.
作者 葛苗苗 蔡春
机构地区 旷东医学院湛江科研中心
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2014年第9期839-850,共12页 Progress In Biochemistry and Biophysics
基金 国家自然科学基金资助项目(21375029) 广东医学院研究团队基金资助项目(TD1125)~~
关键词 5-羟甲基胞嘧啶 TET蛋白 早期胚胎发育 5-hydroxymethylcytosine, TET proteins, early embryonic development
分类号 Q523 [生物学—生物化学] R34 [医药卫生—基础医学]
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共引文献21

同被引文献101

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生物化学与生物物理进展
2014年 第9期

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