WT1介导的转录调控通路与白血病

WT1-Mediated Pathway of Transcriptional Regulation and Leukemia

WT1基因编码的锌指转录因子能调控下游基因的转录,其中很多靶基因涉及调节细胞周期和增殖分化,而WT1本身也接受其上游基因的调控,如NF-κB和GATA-1等,这样便构成WT1介导的转录调控通路,参与造血系统发育的调控。如果转录因子的表达脱调控以及随之而来的正常基因表达态势受干扰,常会引起造血细胞的增殖、分化及凋亡动态平衡的紊乱,最终导致白血病。本文就WT1介导的转录调控通路与白血病的关系作一综述。

WT1 gene encodes a zinc-finger transcription factor that regulates transcription of its downstream genes.Some of target genes for WT1 are involved in regulating both cell cycle and cellular proliferation and differentiation.However,WT1 itself is regulated by its upstream genes,such as NF-kB and GATA-1.Thus there exists a pathway of transcriptional regulation mediated by WT1,which controls development of hematopoietic system.Leukemia results from disrupting the homeostasis among hematopoietic proliferation,differentiation and apoptosis,which is often the consequence of an inappropriate expression of transcription factors and subsequent disruption of the normal gene expression pattern.This article reviews the relationship between the WT1-mediated pathway of transcriptional regulation and leukemia.