急性白血病患者血脂变化及临床意义

Alteration of Serum Lipids in Patients with Acute Leukemia and Its Clinical Significance

为探讨急性白血病(AL)患者血脂的变化及其临床意义,用全自动生化分析仪检测了86例AL患者血脂的含量。结果显示,AL患者甘油三酯(TG)较正常对照组显著升高(P<0.05),总胆固醇(TC),低密度脂蛋白-胆固醇(LDL-C)和高密度脂蛋白-胆固醇(HDL-C)较正常对照组显著降低(P<0.05);AL患者化疗后达完全缓解者TG较治疗前显著降低(P<0.05),TC,LDL-C及HDL-C显著升高(P<0.05);未缓解者上述各项指标均无显著变化。结论:监测血脂水平的变化对AL患者的疗效判断和病情监测是一项简单而又重要的辅助指标。

To explore the clinical significance on alteration of serum lipids in r.cute leukemia(AL) patients,the level of serum lipids was monitored in 86 AL cases by using of automatic biochemical analyzer.The results showed that TG was significantly higher ( P <0.05) while TC,LDL-C and HDL-C were obviously lower( P <0.05) in AL patients than those in normal controls.After chemotherapy,TG decreased but TC,LDL-C and HDL-C were still higher( P <0.05) as comparing to pre-treatment in complete remission cases.There were no changes of those parameters in non-remission patients.It is concluded that determination of serum lipids level in AL patients is a simple and important accessory index to evaluate curative effect and monitor patient's condition.