慢性特发性中性粒细胞减少症患者血清G-CSF水平测定及其意义

Determination of Serum Granulocyte Colony-Stimulating Factor Level in Patients with Chronic Idiopathic Neutropenia and Its Significance

检测慢性特发性中性粒细胞减少症(CIN)患者血清粒细胞集落刺激因子(G-CSP)水平并探讨其意义。采用酶联免疫吸附法(ELISA)测定CIN患者40例血清G-CSF水平,并与系统性红斑狼疮(SLE)并中性粒细胞减少患者40例及正常对照组40例血清G-CSF水平进行比较分析。结果发现,正常对照组及SLE组血清G-CSF检出率分别为11/40和10/40,两者血清G-CSF水平无差别,分别为(27.34±8.00)ng/L及(26.76±7.26)ng/L;CIN患者血清G-CSF检出率为27/40,血清G-CSF水平为(134.04±89.29)ng/L,高于正常对照组及SLE组(P<0.01)。结论:CIN患者可能存在G-CSF利用障碍。

To investigate the serum granulocyte colony-stimulating factor (G-CSF) level in patients with chronic idiopathic neutropenia (CIN) and analyze its clinical significance.By the use of G-CSF-specific enzyme-linked immunosorbent assay (ELISA),the serum levels of G-CSF were determined in 40 cases with chronic CIN,40 cases with systemic lupus erythematosus (SLE) complicated neutropenia and 40 healthy volunteer (normal control) .Results showed that serum G-CSF was positive in 11 normal controls and in 10 cases with SLE,and the G-CSF levels were (27.34 + 8.00)ng/L and (26.76 + 7.26)ng/L,respectively.Serum G-CSF in 27 cases with CIN was positive,the level was (134.04 + 89.29)ng/L,which was higher than that in the normal controls and the cases with SLE ( P < 0.01) .It was concluded that an obstacle to utilization of G-CSF could be existed in the patients with CIN.