5%葡萄糖注射液对盐酸胺碘酮注射液所致静脉炎的效果评价

The Effect of 5% Dextrose Infusion for Phlebitis Caused by Amiodarone

目的探讨5%葡萄糖注射液对胺碘酮所致静脉炎的效果。方法将2011年6月-2012年3月收治的136例患者随机分为对照组63例和干预组73例。对照组遵医嘱以5%葡萄糖注射液500 mL加胺碘酮注射液600 mg以15滴/min静脉输注,1次/d,连续使用3 d;干预组在对照组输液治疗的基础上同时以5%葡萄糖注射液冲管,比较两组患者静脉炎并发症的发生率。结果对照组发生静脉炎22例(34.9%),干预组发生静脉炎11例(15.0%),两组比较差异有统计学意义(χ2=7.252,P=0.007)。结论输液治疗同时以5%葡萄糖注射液冲管可明显降低胺碘酮所致静脉炎的发生。

Objective To investigate the effect of 5% dextrose intravenous infusion for phlebitis caused by amiodarone. Methods A total of 136 patients treated in our hospital between June 2011 and March 2012 were randomly assigned into control group with 63 patients and intervention group with 73 patients. The control group was administrated 600 mg amiodarone with 15 drops/minute intravenous injection once daily, for 3 days, while for the intervention group patients, we added 5% dextrose solution infusion in the same channel at the same time. Results Phlebitis occurred in 22 patients （34.9%） in the control group, while the intervention group had only 11 （15.0%） （χ2=7.252,P=0.007）. Conclusion Infusion of 5% dextrose solution can significantly reduce the occurrence of phlebitis caused by amiodarone.