期刊文献+

N-乙酰氨基葡萄糖转移酶-Ⅴ与恶性肿瘤增殖和侵袭转移的关系 被引量:7

原文传递
导出
摘要 β1,6分支型N-糖链是一类由N-乙酰氨基葡萄糖转移酶-Ⅴ催化生成的糖蛋白,位于细胞表面,其生物活性的变化与细胞的生物行为直接相关,参与细胞增殖,增强肿瘤细胞侵袭、转移能力。因此,对N-乙酰氨基葡萄糖转移酶-Ⅴ的生物功能的全面了解有助于对肿瘤发病机制的进一步把握,从而为恶性肿瘤的治疗提供指导。
作者 杨娟 陈杰
出处 《华西医学》 CAS 2014年第9期1779-1782,共4页 West China Medical Journal
  • 相关文献

参考文献31

  • 1Dennis JW, Laferte S, Waghorne C, et al. Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis[J]. Science, 1987,236(481): 582-585.
  • 2Granovsky M, Fata J, Pawling J, et al. Suppression of tumor growth and metastasis in Mgat5-deficient mice[J]. Nat Med, 2000, 6(3): 306-312.
  • 3Saito H, Gu J, Nishikawa A, et al. Organization of the human N-acetylglucosaminyltransferase V gene[J]. Eur J Biochem, 1995, 233(1): 18-26 .
  • 4Ko JH, Miyoshi E, Noda K, et al. Regulation of the GnT- V promoter by transcription factor Ets-I in various cancer cell lines[J]. J Bioi Chern, 1999,274(33): 22941-22948.
  • 5Buckhaults P, Chen L, Fregien N, et al. Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene[J]. J Bioi Chern, 1997,272(31): 19575-19581.
  • 6Chen L, Zhang W, Fregien N, et al. The her-2/neu oncogene stimulates the transcription of N-acetylglucosaminyltransferase V and expression of its cell surface oligosaccharide products[J]. Oncogene, 1998, 17(16): 2087-2093.
  • 7Taniguchi N, Miyoshi E, Ko JH, et al. Implication of N-acetylglucosaminyltransferases m and V in cancer: gene regulation and signaling mechanism[J]. Biochim Biophys Acta, 1999,1455(2/3): 287-300.
  • 8Liithy R, Mclachlan AD, Eisenberg D. Secondary structure-based profiles: use of structure-conserving scoring tables in searching protein sequence databases for structural similarities[J]. Proteins, 1991,10(3): 229-239.
  • 9Ihara S, Miyoshi E, Nakahara S, et al. Addition ofbetal-6 GlcNAc branching to the oligosaccharide attached to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and resistance against trypsin[J]. Glycobiology, 2004,14(2): 139-146.
  • 10Ihara S, Miyoshi E, Ko JH, et al. Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching[J]. J BioI Chern, 2002, 277(19): 16960-16967.

同被引文献36

引证文献7

二级引证文献37

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部