卵子成熟障碍综合征的特征及分子机制

Feature and Molecular Mechanism of Oocyte Maturation Failure Syndrome

卵子成熟障碍发生于体外受精技术的促排卵过程中,如果反复发生且不能通过卵子体外成熟培养来解决时,即称为卵子成熟障碍综合症。根据卵子减数分裂阻滞在不同的时期将卵子成熟障碍综合症分为GV期阻滞、MI期阻滞、MII期阻滞和混合型阻滞。目前认为,卵子体内成熟过程中的不同时期的主要信号传导通路障碍,将导致不同类型的卵子成熟障碍的发生。

Oocyte maturation failure occurs during the progress of controlled ovarian hyperstimulation in in vitro fertilization cycle. If it occurs repeatedly and the arrested oocytes could not complete maturate in vitro, it is called oocyte maturation failure. According to the oocyte meiotc arrest at different periods, oocyte maturation syndrome can be divided into GV stage blockage,M_Ⅰ stage blockage, M_Ⅱ stage blockage and mixed stage blockage. Presently, the main signal transduction disorder in different periods ofoocyte maturation leads to the occurrence of different stages of oocyte maturation failure syndrome.