摘要
目的 比较和分析不同性别间膀胱尿路上皮癌临床病理学特征的差异.方法 复习458例膀胱尿路上皮癌患者的临床病理资料,重新阅读所有存档病理切片,依据WHO（2004）膀胱尿路上皮癌病理学分级和TNM分期标准进行分级和分期.236例有随访结果.结果 458例膀胱尿路上皮癌中,男性369例,女性89例,男女之比为4.1∶1.初次诊断时的平均年龄,男性为70.3岁（30 ～ 94岁）,女性为67.7岁（34 ～ 93岁）,发病年龄差异不显著（P＞0.05）;肿瘤复发率,男性232例（62.9％）,女性54例（60.7％）,差异不显著（P＞0.05）;2年内复发率均＞40％.在初发癌和复发癌的病理学分期上,与男性相比,女性患者的病变更多是非浸润性的（pTa,P＜0.05）,局部进展（黏膜内浸润）的风险较低（pT1,P＜0.05）;在浸润至肌层以下分组中（≥pT2）,两性间差异不显著（P＞0.05）;组织学分级上,两性间亦无显著性差异（P＞0.05）.膀胱尿路上皮癌不同性别间总生存率差异不显著（P＞0.05）.结论 膀胱尿路上皮癌发病具有明显的性别差异,男性发病率是女性的4.1倍,与男性相比,女性病变更多是非浸润性的,局部进展（黏膜内浸润）风险较低,但膀胱尿路上皮癌不同性别间总生存率差异不显著.
Objective To analyze the clinicopathological differences in human bladder cancer between different gender. Method A total of 458 bladder cancer patients were included in this study, and their clinical and pathological data were reviewed. The histologic diagnosis of tumors was based on the WHO 2004 classification of bladder cancer. The follow- up data were obtained in 236 patients. Results Among the 458 patients, there were 369 cases of female and 89 cases of male （ ratio = 4. 1 ： 1 ）. The average age at initial diagnosis was 70. 3 in male and 67.7 in female, and there was no significant difference between male and female in the onset age of bladder cancer （ P 〉 0.05 ）. There was no significant difference of the tumor recurrence rate between male （ 62. 9% ） and female （ 60. 7% ） （ P 〉 0. 05 ）. The two-year recurrence rate were both more than 40% o There was no significant difference between male and female in pathological grading （ P 〉 0. 05 ）. In female, there were more non-muscle invasive （ pTa and pT1 ） bladder cancers than those in males. There was no significant difference in over all survival between male and female （ P 〉 0. 05 ）. Conclusion The incidence of bladder cancer is higher in men than that in women. Bladder cancer in women, compared in men, is less invasive and probably less progressire. No significant difference in over all survival is observed between men and women.
出处
《诊断病理学杂志》
CSCD
北大核心
2014年第9期546-548,共3页
Chinese Journal of Diagnostic Pathology
