摘要
目的研究胃癌组织趋化因子受体3(CCR3)的表达及临床意义。方法收集胃癌组织标本62例,采用FQ-PCR和免疫组化法检测胃癌癌组织、癌旁组织及正常胃组织中CCR3mRNA及蛋白表达,分析其病理临床意义。结果 62例中,胃癌癌组织CCR3mRNA及蛋白的表达量高于癌旁组织和正常胃组织(P<0.05);CCR3mRNA及蛋白的表达量与胃癌分化程度、淋巴结转移相关(P<0.01),与患者年龄、性别、肿瘤大小、肿瘤部位、肿瘤分期和浸润深度无关(P>0.05)。结论CCR3在胃癌癌组织中表达水平明显升高,并与胃癌分化程度及淋巴结转移密切相关;CCR3可成为临床治疗的潜在靶点。
Objective To investigate the expression and significance of chemokine receptor （CCR3） in gastric cancer. Methods The expressions of CCR3 rnRNA and protein were detected by FQ-PCR and immunohistochemical staining in 62 speciments of gastric cancer（group A）, tumor adjacent tissues（group B） and normal gastric tissues（group C）. The relationship of CCR3 expression and clinical pathological characteristics was analyzed. Results The expression of CCR3 mRNA was significantly higher in group A than that in groups of B and C（P〈0. 05）. The expression of CCR3 mRNA was correlated with the differentiation and lymph node metastasis （P〈0. 01）, but not correlated with the age, gender, tumor size and location, clinical stage and infiltration depth （P〈0. 05）. Condasion The expressions of CCR3 mRNA and protein are significantly higher in gastric cancer, which are closely related with the differention and lymph node metastasis and may become a potential target for clinical therapy.
出处
《江苏医药》
CAS
北大核心
2014年第18期2129-2132,F0002,共5页
Jiangsu Medical Journal
基金
江苏省科技厅临床医学研究中心(BL2012008)
关键词
趋化因子受体3
胃癌
Chemokine receptor 3
Gastric cancer
