ADAM33基因多态性与东北汉族银屑病的相关性

Association of ADAM33 gene polymorphism and psoriasis in Northeastern Chinese Han population

目的:确定解整合素金属蛋白酶(ADAM33)基因与东北地区汉族人群银屑病的相关性。方法:利用多重SNaPSHOT方法检测东北汉族400例银屑病患者和398名正常对照的ADAM33基因中rs2787094、rs512625、rs597980位点的基因分型。比较患者和对照组间、不同临床表型组间的基因型、等位基因和单体型频率分布的差异性。结果:ADAM33基因rs2787094CC、CG基因型和2个单体型(H3和H5)可能为银屑病的危险因素(P<0.05),rs512625AA基因型和3个单体型(H1、H4和H7)可能是银屑病的保护因素(P<0.05)。rs597980的基因型和等位基因在病例和对照组间无差异(P>0.05)。rs2787094CC基因型和C等位基因可能与晚期发病和/或无家族史的患者具有相关性,与病情严重程度和性别无关。结论:ADAM33基因的多态位点与东北地区汉族人群银屑病具有相关性。

Objective： To determine the association between ADAM33 and psoriasis in the northeastern Han population. Methods：Three common single nucleotide polymorphisms （ SNPs） （ rs2787094, rs512625 and rs597980） from ADAM33 were genotyped in 400 patients with psoriasis and 398 controls from the north-eastern Han population using a Multiplex SNaPSHOT method. SNPs genotypes and alleles frequencies were an-alyzed by SPSS 13.0. Rs2787094 CC genotype and C allele were compared between the patients and controls, as well as between patients with different clinical phenotypes of psoriasis. Results：The rs2787094CC CG gen-otypes （P〈0.05） and 2 haplotypes were associated with an increased risk of psoriasis （H3, H5; P〈0.05）. The rs512625AA genotype and 3 haplotypes （ H1, H4, H7） were found to be a protective factor against psori-asis （ P〈0.05） . Rs2787094CC genotype and C allele were associated with patients both in the late onset group and/or in the sporadic group （ P〈0.05） . Conclusion：ADAM33 is associated with psoriasis in the northeast-ern Han population.