蛋氨酸硒联合NB-UVB治疗银屑病疗效及对TNF-α水平的影响

Assessment of efficacy of selenium methinolne combined with NB-UVB in the treatment of psoriasis vulgaris and of the influence on the TNF-α level

目的:评价蛋氨酸硒联合NB-UVB照射治疗寻常型银屑病的疗效及对血清TNF-α的影响。方法:将73例患者随机分为两组,治疗组39例,采用NB-UVB照射,隔日1次,同时口服蛋氨酸硒(100μg/片)。对照组34例,采用NB-UVB照射,隔日1次。治疗4周后观察疗效并测定血清中TNF-α和Se含量。结果:治疗组与对照组有效率分别为89.74%和70.59%,两组差异有统计学意义(P<0.05);两组TNF-α水平治疗前后分别为1.76±0.35、1.41±0.48和1.67±0.44、1.43±0.41,治疗后均明显降低(P<0.05),但两组间差异无统计学意义(P>0.05)。结论:Se联合NB-UVB照射治疗寻常型银屑病疗效优于单用NB-UVB照射,但对于降低TNF-α水平二者可能无协同作用。

Objective：To assess the efficacy of selenium methinoine （ SeMet） combined with narrow-band ultraviolet B （ NB-UVB） in the treatment of psoriasis vulgaris （ PV） and of the influence on the serum TNF-α levels. Methods：Seventy-three patients with PV were randomly divided into treatment group and control group. The patients （39） were treated with NB-UVB （every other day） and oral SeMet （twice daily）. The patients （ 34） in control group were treated with NB-UVB （ every other day） and oral placebo （ twice daily） . The duration of the treatment was 4 weeks. The efficacy and the serum level of TNF-αand Se were tested. Re-sults：The total effective rate in treatment group was 89.74% and 70.59% in the control group, with a signifi-cant difference between the two groups （P〈0.05）. The TNF-α level after treatment was decreased in both groups （ P〈0.05） , but the decreasing level was no significant difference between the two groups （ P〉0.05） . Conclusion： The combination of NB-UVB with oral SeMet was more effective than NB-UVB alone in the treatment of PV. However, Se may be not a synergic factor with NB-UVB in decreasing TNF-α level.