纳秒脉冲肿瘤消融的研究进展

Research Advances in the Tumor Ablation Induced by Nanosecond Pulse

目前,癌症仍然是全世界人类死亡的主要原因,而且患者人数不断上升。探索新型有效的癌症治疗手段刻不容缓。本文阐述了癌症的十个主要生物学特征,介绍了纳秒脉冲靶向癌症生物学特征的肿瘤消融的独特优点:包括诱导细胞凋亡,抑制血管生成,破坏肿瘤微环境等,并重点综述了纳秒脉冲肿瘤消融在皮肤黑色素瘤、基底细胞癌、鳞状细胞癌、肝细胞癌以及其他肿瘤中的研究应用。最后对纳秒脉冲的临床应用前景进行了展望。

Cancer remains a leading cause of human death worldwide and the total number of cases globally is increasing constantly, thus it is urgent to explore new and effective therapies for the cancer treatment. This paper reviewed 10 primary biological hallmarks of the cancer, introduced the distinguished advantages of tumor ablation induced by nanosecond pulse targeting tumor biological hallmarks, such as inducing cell apoptosis, inhibiting angiogenesis, destroying tumor micro-environment. We also elaborated the research progress of tumor ablation induced by nanosecond pulse employed in the treatment of cutaneous melanoma, basal cell carcinoma, squamous cell carcinoma, hepatocellular carcinoma and other tumors, showing an attractive application prospect.