穴位埋线治疗围绝经期综合征临床对照研究

Acupoint catgut embedding for perimenopausal syndrome:a clinical controlled trial

目的:比较穴位埋线与坤泰胶囊治疗围绝经期综合征的临床疗效差异,为围绝经期综合征的治疗提供有效疗法。方法:埋线组33例行穴位埋线治疗,以肝脾肾俞募配穴为主方,配合辨证和辨病取穴相结合,10天埋线1次;坤泰胶囊组口服坤泰胶囊,每次4粒,每天3次,分别在治疗前、治疗10天、30天和60天时观察两组患者Kupperman指数(KI)评分,并根据KI比值的改变评定疗效。结果:治疗后两组均随着治疗时间的延长,KI评分、KI比值逐渐下降,且治疗10天后埋线组KI评分、KI比值均低于坤泰胶囊组(均P<0.05);治疗10天后,埋线组总有效率为36.4%(12/33),优于坤泰胶囊组的3.0%(1/33,P<0.05),而治疗30天后、60天后以上各项指标组间差异均无统计学意义(均P>0.05)。结论:穴位埋线与坤泰胶囊均可降低KI评分,改善患者临床症状,且穴位埋线在治疗早期有一定疗效优势。

Objective To compare the clinical efficacy differences between acupoint catgut embedding and Kuntai capsule for perimenopausal syndrome, so as to provide an effective treatment method for perimenopausal syndrome. Methods Thirty-three cases in the embedding group were treated with acupoint catgut embedding at back-shu points and front-mu points of liver, spleen and kidney combined with syndrome differentiation and disease differentiation, ten days per times; the Kuntai group was treated with oral administration of Kuntai capsule, 4 capsules each time, three times per day. The Kupperman index （KI） was observed in the two groups before treatment after 10 days, 30 days and 60 days of treatment, respectively; the efficacy was evaluated according to the ratio of KI. Results After the treatment, as treat- ment proceeded, the score of KI and ratio of KI were gradually reduced in two groups; the score of KI and ratio of KI in the embedding group after 10 days of treatment was lower than those in the Kuntai group （both P〈0. 05） ; after 10 clays of treatment, the total effective rate was 36.4% （12/33） in the embedding group, which was superior to 3.0% （1/33） in the Kuntai group （P〈0.05） ; however, after 30 days and 60 days of treatment, the differences of each index between two groups were not statistically significant （all P〉0.05）. Conclusion Both the acupoint catgut embedding and Ku^tai cap- sule could reduce the score of KI and improve clinical symptoms, and the acupoint catgut embedding has certain advantage on the early stage of treatment.