抗菌骨修复材料HAPw/n-ZnO在拔牙位点保存中的实验研究

Experiment Research of Antibacterial Bone Repair Materials HAPw/n-ZnO at a Tooth Site Preservation

目的探讨局部应用HAPw/n-ZnO对兔拔牙创愈合的影响。方法选用健康大耳白兔45只,雌雄不限,随机分为实验组(HAPw/n-ZnO)15只、阳性对照组(Bio-oss骨粉组)15只和阴性对照组(空白组)15只;拔除右下颌中切牙后,实验组即刻植入HAPw/n-ZnO复合材料,阳性对照组植入Bio-oss骨粉,阴性对照组不作任何处理,术后于1、2、4、8、12周分别处死3只兔子,行大体观察、影像学观察及组织病理学观察。结果实验组与阴性对照组,阳性对照组与阴性对照组之间剩余牙槽嵴相对长度的比较有统计学意义(P<0.05),而实验组与阳性对照组之间剩余牙槽嵴相对长度的差异无统计学意义(P>0.05)。组织学结果显示实验组和阳性对照组比同期阴性对照组的成骨活跃且新生骨成熟度高,实验组与阳性对照组间无明显差别。结论局部应用HAPw/n-ZnO复合材料或Bio-oss骨粉均具有保存拔牙后剩余牙槽嵴长度的作用,HAPw/n-ZnO复合材料可单独应用于拔牙位点保存的骨移植材料。

Objective To investigate the effects of local application HAPw/n-ZnO on healing after tooth extraction in rabbits.Methods Totally 45 rabbits,male and female unlimited,were divided into experimental groups （HAPw/n-ZnO）,positive control groups （Bio-oss） and the negative control group（The blank）（15 rabbits/in each group）.Rabits in experimental groups were immediately implanted HAPw/n-ZnO in extraction sockets of the mandibular incisor,Bio-oss in positive control groups.Nothing was made in negative control group.The clinical,the radiology,and the histopathological were then observed and analyzed at 1,2,4,8 and 12 weeks postoperative.Results Compared with the negative control groups,the relative length of residual alveolar ridge of the experimental groups and the negative control groups was statistical significance （P ＜ 0.05）,but no statistical significance （P ＞ 0.05） between the experimental groups and positive control groups.Histological results revealed that in the same period the osteogenesis active and the new bone＇s maturation of the experimental groups and the positive control groups was higher than the negative control groups,but there was no evident difference between experimental groups and the positive control groups.Conclusion HAPw/n-ZnO and Bio-oss have the effect of protecting the residual alveolar ridge.HAPw/n-ZnO can be applied alone in the tooth extraction sites preservation.