喉组织的肿瘤浸润“屏障”与“通道”的组织切片研究

Study on the "Barrier" and "Channel" in the Role of the Larynx Tissue Section

目的研究各喉组织在喉癌细胞浸润和扩散过程中的"屏障"与"通道"作用。方法选取结构完整的华北地区正常成年尸喉30例,进行全喉连续切片,行HE染色脱蜡封片后在光镜下观察。结果喉的前联合、喉软骨及软骨膜、甲状舌骨膜、舌骨会厌韧带、甲状会厌韧带、方形膜、弹性圆锥、Reinke间隙等是肿瘤侵袭"屏障"。而环甲膜、声门旁间隙、会厌前间隙及环区则是肿瘤浸润转移的重要"通道"。结论喉部存在可以阻止肿瘤浸润的"屏障",但也有"通道"可供其扩散,了解喉部各组织的组织屏障作用可为临床手术治疗提供参考和依据。

Objective To study the ＂barrier＂ and ＂channel＂ in the role of the larynx in laryngeal tissue infiltration and proliferation processes.Methods The complete structure of the 30 normal aduls＇t cadaver larynx in North China was Selected,and they were put into serial sections.Then the slides were looked under the light microscope after dewaxing HE staining were mounted.Results Laryngeal anterior commissure,larynx cartilage and perichondrium,hyothyroid membrane,hyoepiglottic ligament,thyroepiglottic ligament,quadrangular membrane,conus elasticus and Reinke clearance were the tumor invasion ＂ barrier.＂ The cricothyroid membrane,paraglottic space,preepiglottic space and cricoid area were important tumor invasion and metastasis ＂ channel＂.Conclusion Larynx has the ＂ barrier＂ which can prevent tumor invasion,but also has the＂ channel＂ available for its diffusion.Learn the Laryngeal tissue barrier function of the organizations will provide reference and basis for clinical surgery.