脓毒症相关性脑病在ICU发生的危险因素分析

Clinical Analysis of Risk Factors of Sepsis-Associated Encephalopathy in ICU

目的 探讨重症监护病房中脓毒症患者并发脓毒症相关性脑病（sepsis-associated encephalopathy）的流行病学特点及危险因素。方法 回顾性分析2012年9月～ 2013年9月笔者医院ICU收治220例脓毒症患者的临床资料,比较发生SAE组与非SAE组患者的年龄、性别构成、病死率、住院时间、住ICU时间、病原学资料、血常规、电解质、肝肾功能、血气、APACHEII评分.结果 脓毒症相关性脑病的发生率为39.55％,两组患者的住院时间、住ICU时间、G-及G＋菌检出率、WBC、K＋、TBIL、PaO2、PaCO2水平差异均无统计学意义,然而两组患者病死率、真菌检出率、ALT、AST、DBIL、pH值、APACHEⅡ评分差异有统计学意义.结论 APACHEⅡ评分、ALT、AST、pH值是SAE发生的危险因素。

Objective To learn the factors of sepsis-associated encephalopathy（SAE）.Methods A total of 220 patients with septic admitted to our Intensive Care Unit（ICU）from Sept.2012 to Sept.2013 in our hospital,were analyzed retrospectively.The samples were divided into SAE group and NE group.A contrastive analysis was performed on the epidemiological data（age,sexual,morbidity,mortality,time of stay in ICU,length of hospital stay,etc.）,and the results of related examination （WBC,ALT,AST,TBIL,DBIL,PaO2,PaCO2,A-PACHE Ⅱ scores,etc.）.Results SAE incidence was 39.55％.The results of mortality,The detection rate of fungi,ALT,AST,DBIL,PH value and APACHE Ⅱ scores showed a statistical difference between 2 groups （P ＜ 0.05）.Conclusion It is of great significance to determine APACHE Ⅱ,ALT,AST and PH value in diagnosis and prevention of SAE.