富血小板血浆在临床骨科中的应用进展

APPLICATION OF PLATELET-RICH PLASMA IN CLINICAL ORTHOPEDICS

目的总结富血小板血浆(platelet-rich plasma,PRP)在临床骨科中的应用现状及进展。方法查阅近年国内外有关PRP在临床骨科中应用的相关研究,并进行总结分析。结果近年来有大量PRP应用于骨、软骨、韧带、肌腱、肌肉和其他软组织的临床研究报道,涉及骨缺损/骨不连、脊柱融合、骨关节炎和软骨损伤、韧带重建后的愈合、肌肉拉伤、肌腱末端病和各种急慢性软组织损伤等多种疾病,但其结果不一。结论 PRP因来源于自体、取材简便、以生物学修复为目标及肌肉骨骼系统组织修复潜能等优点被广泛应用于骨科临床,但目前PRP应用于骨科实践仍缺乏统一公认的应用标准和可靠的临床指南,尚需要更大样本、更高质量的临床证据来进一步支持其应用于骨科临床各种疾病的安全性和有效性。

Objective To summarize the application status and progress of platelet-rich plasma（PRP） in clinical orthopedics. Methods The recent related literature concerning the application of PRP in clinical orthopedics was extensively reviewed and analyzed. Results Recently, a large number of clinical studies on PRP have been carried out, which are applied in bone defects or nonunion, spinal fusion, osteoarthritis and cartilage injuries, ligament reconstruction, muscle strain, tendon terminal diseases, and a variety of acute and chronic soft tissue injuries. Some results show certain effectiveness, while others demonstrate invalid. Conclusion Easily drawing, achieving autologous transplantation, and the biological repair potential of the musculoskeletal tissues make PRP to be widely used in clinical orthopedics. However, there are still no uniform standards accepted and reliable clinical guidelines about the application of PRP. Furthermore, a variety of PRP products and their respective indications are also different. The clinical evidences with the greater sample size and higher quality are still needed to further support the safety and effectiveness of PRP in clinical orthopedics.