法舒地尔治疗AECOPD相关性肺动脉高压患者的临床近期疗效分析

Clinical short-term effect analysis of fasudil in treatment of patients with AECOPD associated pulmonary arterial hypertension

目的探讨法舒地尔治疗慢性阻塞性肺疾病急性加重期（AECOPD）相关性肺动脉高压的临床近期疗效。方法选取本院2010年10月-2013年10月诊治的AECOPD相关性肺动脉高压患者110例,采用随机数字表法分为两组,55例患者实施常规治疗为对照组,55例患者在常规治疗基础上加用法舒地尔治疗为观察组,比较两组患者肺功能指标的改变情况、相关指标的改变情况、治疗效果。结果治疗后,两组患者FEV1（1s用力呼气容积）、FVC（用力肺活量）、FEV1/FVC（气道阻塞的肺量测定）、血氧饱和度、动脉血氧分压、6min步行距离均显著增加,而肺动脉收缩压均显著降低。观察组患者FEV1、FVC、FEV1/FVC、血氧饱和度、动脉血氧分压、6min步行距离、总有效率均明显高于对照组,观察组患者肺动脉收缩压明显低于对照组,差异均有统计学意义（P〈0.05）。结论法舒地尔是治疗AECOPD相关性肺动脉高压的有效药物,可明显改善患者的心肺功能,临床近期疗效显著,值得临床推广使用。

Objective To investigate clinical short-term effect of fasudil in treatment of AECOPD associated pulmonary arterial hypertension. Methods 110 patients with AECOPD associated pulmonary arterial hypertension were selected in hospital from October 2010 to October 2013, who were randomly divided into two groups. 55 patients received routine treatment as control group. 55 patients treated fasudil basing on routine treatment as observation group. Changes of lung function indexes; changes of related indexes; treatment effect were compared between two groups. Results After treatment, FEV1; FVC; FEV1/ FVC; oxygen saturation; arterial partial pressure of oxygen; 6min walking distance increased obviously while pulmonary artery systolic pressure decreased significantly in two groups. FEV1; FVC; FEV1/ FVC; oxygen saturation; arterial partial pressure of oxygen; 6min walking distance; total efficiency in observation group were significantly higher than control group. Pulmonary artery systolic pressure in observation group was significantly lower than control group. Difference was statistically significant（P 〈0.05）. Conclusion Fasudil is an effective drug in treatment of AECOPD associated pulmonary arterial hypertension, which can significantly improve heart and lung function of patients. Fasudil has significant clinical short-term effect, which is worthy of clinical use.