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IL-33及其受体ST2的研究进展 被引量:8

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摘要 IL-33是IL-1家族的新成员,是炎症反应和免疫偏倚的重要调节因子之一,主要诱导Th2型免疫。IL-33正常情况下存在于细胞核中,作为转录因子发挥作用,当细胞受到损伤时可分泌IL-33至胞外后与受体ST2结合,从而作为细胞因子发挥作用。这一过程对正常细胞生物学功能的发挥和多种疾病的发生发展都密切相关。
出处 《现代免疫学》 CAS CSCD 北大核心 2014年第5期425-428,385,共5页 Current Immunology
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