外周血中CD4^+CD25^+Tregs与慢性乙型肝炎抗病毒治疗相关性的研究进展

Advances in understanding relationship between peripheral blood CD4^+CD25^+regulatory T cells and antiviral treatment in CHB patients

CD4+CD25+调节性T细胞(T regulatory cells,Tregs)发挥的免疫负调作用与慢性乙型肝炎发生、发展及预后密切相关,慢性乙型肝炎患者在抗病毒治疗过程中外周血CD4+CD25+Tregs呈现的变化以及发挥的作用备受诸多学者关注,本文就CD4+CD25+Tregs的分类、免疫标志、功能及其与CHB抗病毒的相关研究进行综述.

The immunosuppressive function of CD4^＋ CD25^＋ regulatory T cells may closely associate with the occurrence, development and prognosis of CHB patients. The change and function of CD4^＋CD25^＋ regulatory T cells in CHB patients undergoing antiviral treatment have aroused the attention of scholars. Here we review the types, immunophenotypes, and function of CD4^＋CD25^＋ regulatory T cells, as well as the relationship between peripheral blood CD4^＋CD25^＋ regulatory T cells and antiviral treatment in CHB patients.