摘要
目的:研究miR-1290在结直肠癌(colorectal cancer,CRC)患者及健康体检者血浆中的表达差异,并探讨其与临床特征之间的关系.方法:采用实时荧光定量PCR检测检测219例CRC患者及年龄、性别相匹配的45例健康体检者血浆中miR-1290的表达情况,分析其与临床特点之间的关系.结果:在健康体检者与CRC患者两组中,CRC组血浆中miR-1290表达量增高,有统计学意义(P<0.05);以年龄分组(≥60岁,<60岁),高龄组人群中血浆miR-1290的表达水平较低龄组增高,有统计学意义(P<0.05);以性别(男、女)分组,血浆miR-1290的表达水平变化无统计学意义(P>0.05).结论:miR-1290在CRC患者血浆中表达上调,其高表达与CRC的分期相关,有望成为CRC诊断及治疗的指标之一.
AIM： To assess the clinical significance of plasma miR-1290 in patients with colorectal cancer （CRC）.METHODS： Plasma levels of miR-1290 in 219 patients with CRC and 45 healthy subjects were measured using real-time quantitative PCR. The relationship between miR-1290 expression and clinical characteristics of CRC was analyzed. The diagnostic value of miR-1290 for CRC was evaluated. RESULTS： Plasma miR-1290 levels were in- creased significantly in CRC patients compared with healthy controls （P 〈 0.05）. Plasma levels of miR-1290 were not significantly associated with gender （P 〉 0.05）, but were significantly associ- ated with TNM stage and age of patients. CONCLUSION： Increased plasma miR-1290 lev- els are detected in patients with colorectal cancer, which suggests that miR-1290 might be used as a potential marker for colorectal cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第22期3356-3360,共5页
World Chinese Journal of Digestology
基金
广东省第三批重大科技专项基金资助项目
No.2011A080300002
广东省部产学研结合引导基金资助项目
No.2011B090400526
广州市科技和信息化局科技支撑计划基金资助项目
No.2010J-E141~~
