Wnt信号通路与肝纤维化关系的研究进展

Wnt signaling pathway and liver fibrosis: Recent research status

肝纤维化基本病理改变是以肝内弥漫性细胞外基质蛋白(extracellular matrix,ECM)过度沉淀为特点,肝星状细胞(hepatic stellate cell,HSC)的激活被认为是肝纤维化发生的核心和始动环节.目前认为HSC受刺激活化是一个涉及多种细胞因子、细胞信号转导通路间不同水平共同调控的过程.相关研究证实Wnt信号通路在调控肝脏病理生理的过程中起到重要作用,经典Wnt信号通路的异常激活可能是致HSC活化而导致肝纤维化的重要原因.深入探讨肝纤维化过程中Wnt信号通路调控机制,将可能给临床带来更具有价值的诊疗策略.

Hepatic fibrosis is characterized by the excessive accumulation of extracellular matrix（ECM）, and the activiation of hepatic stellate cells（HSCs） is recognized as the core and initial stage. It is reported that the activiation of HSCs is related to the regulation of a series of cell factors and cell signal pathways. The Wnt signaling pathway plays a key role in the physiology and pathology of the liver, and the abnormal activiation of Wnt results in the activiation of HSCs. Therefore, a further understanding of the role of the Wnt signaling pathway in the pathogeneisis of hepatic fibrosis will be valuable in the development of diagnosic and threputic strategies for this disease.