N0期胸段食管癌患者肿瘤长度、直径、体积对其放射治疗后生存状况的影响

Effect of tumor length, diameter and volume on survival of patients with stage N0 thoracic esophageal cancer after radiation therapy

目的:探讨N0期胸段食管癌患者肿瘤长度、直径、体积对其放射治疗后近远期生存状况的影响.方法:选取2007-01/2008-12河南省新乡市中心医院放疗科收治的88例N0期胸段食管癌患者为研究对象,分析患者原发肿瘤靶区(gross tumor volume,GTV)长度、直径、体积对其放疗后近远期生存状况的影响.结果:GTV长度≥5 cm组甲级率与5年生存率分别为14.29%、19.05%低于<5 cm组36.96%、43.48%,肿瘤最大直径>3 cm组甲级率为16.00%,5年生存率为20.00%,均低于直径≤3 cm组39.47%、47.37%,肿瘤体积≥35cm3组甲级率为14.58%,5年生存率为20.83%,均低于直径<35 cm3组40.00%、45.00%.经Cox风险模型分析可知,肿瘤长度、直径是影响患者近期及远期疗效的危险因素.结论:GTV长度、直径、体积可影响N0期胸段食管癌患者放疗后近期疗效及远期生存率,其中肿瘤长度及直径是影响患者近期疗效及远期生存状况的独立危险因素.

AIM： To investigate the effect of tumor length, diameter and volume on the survival of patients with stage N0 thoracic esophageal cancer after radiation therapy.METHODS： Eighty-eight patients with stage N0 thoracic esophageal cancer who received radiation therapy from January 2007 to December 2008 at our hospital were included. The effect of the length, diameter and volume of gross tumor volume（GTV） on the short and long term survival after radiation therapy was analyzed.RESULTS： The complete remission rate and 5-year survival rate were lower in the GTV length ≥ 5 cm group than in the 5 cm group（14.29% vs 36.96%, 19.05% vs 43.48%）. The complete remission rate and 5-year survival rate in the GTV diameter 3 cmgroup were lower than those in the ≤ 3 cm group（16.00% vs 39.47%, 20.00% vs 47.37%）. The complete remission rate and 5-year survival rate in the tumor volume ≥ 35 cm3 group were lower than those in the 35 cm3 group（14.58% vs 40.00%, 20.83% vs 45.00%）. Cox risk model analysis showed that tumor length and diameter were risk factors affecting survival in patients with stage N0 thoracic esophageal cancer. CONCLUSION： GTV length, diameter and volume can affect survival in patients stage with N0 thoracic esophageal cancer after radiotherapy, and tumor length and diameter are independent risk factors for survival of the patients.