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Rational study design for prophylaxis of postoperative nausea and vomiting

Rational study design for prophylaxis of postoperative nausea and vomiting
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摘要 To the editor: In the recent article of Fang and colleagues1 ssessing prophylactic efficacy of a single-dose of dexamethasone before anesthesia induction on postoperative nausea and vomiting (PONV) in patients undergoing microvascular decompression for facial spasm, they showed that dexamethasone did not prevent PONV. Actually, meta-analyses of double-blind randomized controlled trials comparing dexamethasone with controls indicate that this antiemetic is effective in the prophylaxis of postoperative vomiting and reduced use of rescue antiemetics.2 In our views, some limitations of this study design may have made interpretation of their conclusions questionable. To the editor: In the recent article of Fang and colleagues1 ssessing prophylactic efficacy of a single-dose of dexamethasone before anesthesia induction on postoperative nausea and vomiting (PONV) in patients undergoing microvascular decompression for facial spasm, they showed that dexamethasone did not prevent PONV. Actually, meta-analyses of double-blind randomized controlled trials comparing dexamethasone with controls indicate that this antiemetic is effective in the prophylaxis of postoperative vomiting and reduced use of rescue antiemetics.2 In our views, some limitations of this study design may have made interpretation of their conclusions questionable.
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第19期3520-3520,共1页 中华医学杂志(英文版)
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二级参考文献5

  • 1Sato K, Sai S, Adachi T. Is microvascular decompression surgery a high risk for postoperative nausea and vomiting in patients undergoing craniotomy? J Anesth 2013; 27: 725-730.
  • 2Henzi I, Walder B, Tramer MR. Dexamethasone for the prevention of postoperative nausea and vomiting: a quantitative systematic review. Anesth Analg 2000; 90:186-194.
  • 3Banihashem N, Hasannasab B, Alereza H. Does dexamethasone prevent subarachnoid meperidin-induced nausea, vomiting and pruritus after cesarean delivery? Saudi J Anaesth 2013; 7: 138- 141.
  • 4Meng L, Quinlan JJ. Assessing risk factors for postoperative nausea and vomiting: a retrospective study in patients undergoing retromastbid craniectomy with microvascular decompression of cranial nerves. J Neurosurg Anesthesiol 2006; 18: 235-239.
  • 5Tan C, Ries CR, Mayson K, Gharapetian A, Griesdale DE. Indication for surgery and the risk of postoperative nausea and vomiting after craniotomy: a case-control study. J Neurosurg Anesthesio12012; 24: 325-330.

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