青年与老年肺癌患者临床特征及其治疗与预后的差异性研究

Clinical pathological characteristics,treatment and prognosis in young and elder patients with lung cancer

目的:探讨青年肺癌与老年肺癌患者在临床病理特征及其治疗预后上的差异性。方法:回顾性分析我院2000年至2008年期间95例肺癌患者病理资料,包括青年肺癌45例,老年肺癌50例,分析比较两组在临床病理特征及其治疗与预后上的差异性。结果:年龄小于40岁的青年所患肺癌更倾向于腺癌(29/45,64.4%)、低分化(19/45,42.2%)以及Ⅲ+Ⅳ期(25/45,55.6%)肺癌。而老年患者则更倾向于鳞癌和腺癌(45/50,90.0%)、中高分化(41/50,82.0%)以及Ⅰ+Ⅱ期(34/50,68.0%)肺癌,差异均具有统计学意义。而在性别与吸烟史上所表现的差异性无统计学意义。青年肺癌更易于接受手术加术后放化疗治疗的综合治疗(38/45,84.4%),手术率明显高于老年患者,差异具有统计学意义。在预后生存分析中青年肺癌在1、3、5年的生存率(64.34%、30.45%、14.35%)稍高于老年肺癌患者(62.76%、27.26%、11.78%),且差异具有统计学意义。结论:对老年肺癌患者应强调其综合治疗的满意度,而对于青年肺癌患者,更应着重早期发现、早诊断、早治疗。

Objective：To study the clinical pathological characteristics,treatment and prognosis in young and elder patients with lung cancer. Methods：The clinical data of 95 patients with lung cancer included 45 young patients and 50 elder patients were analyzed retrospectively. Results：Young patients have tended to be more adenocarcinoma（29/45,64. 4%）,poorly differentiated（19/45,42. 2%）and Ⅲ ＋Ⅳ stage（25/45,55. 6%）of lung cancer. Elderly pa-tients tend to adenocarcinoma and squamous cell carcinomas（45/50,90. 0%）,high differentiation（41/50,82. 0%） and Ⅰ＋Ⅱstage（34/50,68. 0%）of lung cancer,and the differences were statistically significant. But there were no statistical significance in gender and smoking history. Young patients more easily to accept comprehensive treatment of surgery plus postoperative radiation and chemotherapy treatment（38/45,84. 4%）than elder patients. Prognostic anal-ysis showed that young patients had longer survival in 1,3,5 years（64. 34%,30. 45%,14. 35%）than elder patients （62. 76%,27. 26%,11. 78%）. Conclusion：This differences showed that the comprehensive treatment should be em-phasized for elder patients and early discovery,early diagnosis and early treatment should be emphasized for young pa-tients.