TECIA法体外药敏试验对肺癌术后化疗个体化方案选择的研究

Study on the chemosensitivity test with TECIA in vitro for the choice of individualized chemotherapy of lung cancer

目的:研究新鲜肿瘤组织块体外药敏试验和化疗方案以及生存期的关系,指导肺癌术后化疗方案的选择,实现肺癌个体化药物治疗。方法:采用TECIA法对126例肺癌肿瘤新鲜组织标本进行体外培养,选用临床常用的8种化疗药物进行肿瘤药物敏感性试验,根据试验结果选用化疗方案进行术后辅助化疗,并随访观察生存期。结果:126例标本对常见化疗药高度敏感占1.19%,中度敏感占60.71%;根据药敏结果选用中、高度敏感药物进行术后化疗,其5年生存期延长。结论:根据肿瘤药物敏感试验选用化疗药物能延长生存期,对指导患者的个体化治疗具有一定的指导意义。

Objective：To study the effect of chemosensitivity test in vitro with fresh tumor tissues for lung cancer on chemotherapy and long-term survival. Methods：The sensitivity of 126 lung cancer samples for 8 commonly-used chemotherapeutic drugs was determined by TECIA method,and follow-ups were carried out. Results：Of 126 cases underwent chemosensitivity test with TECIA method,there were 1. 19% very sensitive and 60. 71% moderate sensitive ones. Five-year survivals were extended for those with very sensitive and moderate sensitive cases compared with sensitive resistant ones. Conclusion：The TECIA chemosensitivity test can promote long-term survival of lun-cancer and has potentials to determine the individualized chemotherapy.