胰腺神经内分泌肿瘤临床诊治研究

Diagnosis and treatment of pancreatic neuroendocrine neoplasm

目的:探讨胰腺内分泌肿瘤的外科诊治及近期进展热点。方法:对收治的20例胰腺内分泌肿瘤患者的临床资料进行回顾性分析。结果:20例患者中胰岛素瘤10例,胃泌素瘤5例,无功能性胰岛细胞瘤3例,生长抑素瘤1例,高血糖素瘤1例。其中19例患者给予手术治疗,1例因无法切除而放弃手术治疗。1例患者术后发生胰瘘。所有患者获得随访,随访时间为6个月至2年。3例恶性患者2年内死亡。其他16例良性及1例恶性患者目前生存。结论:正确诊断是胰腺内分泌肿瘤治疗的前提。手术切除是胰腺内分泌肿瘤最为理想的治疗方法,可以延长患者生存时间,改善和控制临床症状。

Objective：To approach the recent advances and hot topics in diagnosis and surgical treatment of pan-creatic endocrine tumors（ PETs）. Methods：The clinical data of 20 pancreatic endocrine tumor patients were retro-spectively analyzed. These patients were treated in Shengjing Hospital of China Medical University between May 2005 and October 2012. Results：10 insulinoma cases,5 gastrinoma cases,3 nonfunctional islet cell tumor cases,1 soma-tostatinoma case and 1 glucagonoma were observed. Of the 20 patients,19 underwent radical resection. The other one had irresectable tumors and thus had to give up surgery. After surgery,one case had pancreatic leakage. The hospital mortality rates of all cases were not determined. The mean follow-up period was 6 months to 2 years. Three malignant tumor patients with relapse or metastasis died within 2 years after surgery. All patients with benign tumors and one ma-glinant tumor patients survived. Conclusion：Avoiding misdiagnosis is important for treatment of PETs. Surgical ap-proach is still considered as the preferred option for curtailing the malignant progression of PETs and controlling the associated biochemical syndromes.