术前介入化疗对局部晚期宫颈癌临床近期疗效分析

Clinical outcomes of interventional chemotherapy for locally advanced cervical cancer before operation

目的:探讨新辅助-动脉灌注化疗(介入化疗)联合手术在子宫颈癌治疗中的临床应用价值。方法:将Ⅰb2-Ⅱb期子宫颈癌患者共68例作为介入化疗组,采取先介入化疗后手术的方案,60例同期Ⅰb2-Ⅱa2期直接手术的对照组作比较。分析近期疗效及术后盆腔淋巴结转移、宫颈浸润深度、切缘阳性情况。结果:Ⅰb2-Ⅱb期宫颈癌病人行新辅助化疗后总有效率为88.2%,各期别间无显著差异(P<0.05)。两组患者手术时间、出血量、住院时间、并发症等比较,差异无统计学意义(P>0.05)。65例介入化疗组术后盆腔淋巴结转移、宫颈浸润深度低于对照组。结论:介入化疗联合手术治疗局部晚期宫颈癌患者可以缩小局部瘤体,降低分期,降低盆腔淋巴结转移率。为手术创造机会,改善患者生活质量,近期疗效显著。

Objective：To investigate the effect of neo adjuvant arterial perfusion chemotherapy（ chemotherapy ） combined operation in treatment of cervical carcinoma. Methods：A total of 68 cases in stageⅠb2 -Ⅱb as the inter-ventional chemotherapy group were compared with the 60 cases of direct operation compared group in stageⅠb2 -Ⅱa2 . Results：Neoadjuvant chemotherapy in stageⅠb2 -Ⅱb cervical cancer patients total efficiency was 88. 23%, there was no significant difference between each other（P〈0. 05）. The two groups of patients in operation time,a-mount of bleeding,hospitalization time,complications were compared had no significant difference（P〉0. 05）. The 65 cases of interventional chemotherapy group postoperative node metastasis,cervical invasion depth was lower than the compared group. Conclusion：Interventional chemotherapy combined with operation in patients with locally advanced cervical cancer can reduce the local tumor staging,reduce pelvic lymph node metastasis rate. Create opportunities for operation. and improve the quality of life of patients.