恶性肿瘤的代谢与免疫逃逸

Tumor cell metabolism and tumor immune escape

恶性肿瘤的发生发展意味着肿瘤细胞适应了不利的环境。肿瘤细胞代谢往往降低线粒体活性和氧化磷酸化过程,在很大程度上依赖有氧糖酵解产生能量。这特定的新陈代谢造成肿瘤微环境的变化,帮助肿瘤细胞得以生存、转移及免疫逃逸,而免疫逃逸包括抑制和阻断肿瘤的免疫反应。这一效应通过许多机制实现,包括肿瘤代谢过程及代谢产物对免疫系统直接和间接的抑制和阻断作用。

Tumorigenesis implies adaptation of tumor cells to an adverse environment. Tumor cell metabolism tends to avoid mitochondrialactivity and oxidative phosphorylation（ OXPHOS）,and largely relies on glycolysis to produceto avoid mitochondrialactivity and oxidative phosphorylation（ OXPHOS）,and largely relies on glycolysis to produce en-ergy. The metabolism result in modificationof the tumor microenvironment,help tumor cells survive,transfer and im-mune escape,and immune escapeincludblockor avoidtumor immune response. This effect is achieved through a number of mechanisms,whichincludeimmunosuppression from tumor metabolism and metabolic products.