白细胞介素-8和细胞间黏附分子-1在早产儿脑白质损伤早期变化及其与预后的关系

Changes of IL-8 and ICAM-1 in early stage of cerebral white matter damage and their correlations with prognosis in premature infants

目的：探讨脑白质损伤（CWMD）早产儿早期血清白细胞介素-8（IL-8）和细胞间黏附分子（ICAM-1）变化及其与预后的关系。方法对2009年3月至2012年6月收治并获得随访的102例CWMD早产儿（CWMD组）和42例正常早产儿（对照组），分别在生后48-72 h采集血清并检测IL-8和ICAM-1含量，12个月时采用Bayley婴幼儿发育量表对婴儿运动发育指数（PDI）及智能发育指数（MDI）进行评估，分析IL-8和ICAM-1水平与预后的相关性。结果轻、中、重CWMD组及对照组间血清IL-8和ICAM-1水平的差异有统计学意义（P〈0.05），且随着CWMD程度加重，IL-8和ICAM-1水平逐渐递增，差异有统计学意义（P均〈0.05）。轻、中、重CWMD组的PDI、MDI的差异有统计学意义（P〈0.05），且随着CWMD程度加重，逐渐递减，差异也有统计学意义（P均〈0.05）。CWMD组的血清IL-8和ICAM-1水平与MDI之间呈显著负相关（r=－0.64、－0.66，P均〈0.05），与PDI之间也呈显著负相关（r=－0.70、－0.71，P均〈0.05）。结论 CWMD早产儿出生后血清IL-8和ICAM-1水平显著增高，并且与其12月龄时的MDI及PDI呈显著负相关。

Objective To explore the IL-8 and ICAM-1 in premature infants with cerebral white matter damage （CWMD） and their correlations with prognosis. Methods One hundred and two cases of CWMD were selected from March 2009 to June 2012 as experimental group and 42 cases of normal preterm children were selected as control group. Serum IL-8 and ICAM-1 levels were measured during 48-72 h after birth. Motor development index （psychomotor developmental index, PDI） and mental development index （mental development index, MDI） were evaluated by Bayley scale. The correlations of IL-8 and ICAM-1 levels with prognosis were analyzed. Results Serum IL-8 and ICAM-1 levels in the experimental group were signiifcantly higher than those in the control group （P〈0.05）. MDI and PDI scores in the experimental group were signiifcantly lower than those in the control group （P〈0.05）. There were negative correlations of serum IL-8 and ICAM-1 levels with MDI （r=-0.64, P〈0.05;r=-0.66, P〈0.05）＋and PDI （r=-0.70, P〈0.05;r=-0.71, P〈0.05）. Conclusions Serum IL-8 and ICAM-1 levels in infants with CWMD are signiifcantly increased, and are negatively correlated with MDI and PDI scores.