白念珠菌唑类药物耐药相关转录因子研究进展

Progress on the transcription factors associated with azole resistance in Candida albicans

近年来白念珠菌的感染率呈逐年上升趋势,随着唑类药物的广泛应用,耐药菌株不断增多,已成为临床治疗的一大难题。白念珠菌的耐药机制主要与ERG11基因的突变和过表达、药物外排泵相关基因表达增多及生物膜的形成等有关,由于转录因子是耐药基因表达的关键调节因子,关于锌簇转录因子与耐药关系的研究越来越多,如TAC1、MRR1、MRR 2、UPC 2、NDT 80等,其点突变可引起某些耐药基因的过表达而介导耐药,该领域研究已成为热点,该文就此研究进展做一概述。

Lately, the rate of Candida albicans infection kept increasing, more and more resistant strains had been detected with the wide use of azoles. Sogreat challenge had been brought to clinical treatment. Some molecular mechanisms associated with azole resistance had been described, including the point mutation , overexpression of target enzyme, increased expression of efflux pump and the formation of biofilm. Since the transcription factors could regulate the expression of drug resistance genes, more and more at- tention has been paid to the contribution of zinc cluster transcription factors to drug resistance, such as TAC 1, MRR 1, MRR 2, UPC 2, NDT 80, and so on. Lots of researches revealed that the point mutations of transcription factors could cause overexpression of their regulated resistance genes and finally led to drug resistance. The review focused on the research progress of the transcription factors.