PhoPR双组份系统在结核分枝杆菌致病机制中的研究进展

PhoP-PhoR two-component signal transduction systems in pathogenesis of Mycobacterium tuberculosis

双组份信号转导系统(Two-component signal transduction system,TCS)广泛存在于原核生物细胞内,对细胞生长、分化、代谢、毒力、持留性、致病性等方面的调控发挥着重要作用。PhoPR TCS作为双组份系统中最基本、最重要的感应外界环境变化,并作出相应反应的调控系统,能够调控结核分枝杆菌(Mycobacterium Tuberculosis,MTB)更好的适应宿主微环境变化。因此PhoPR TCS作为MTB适应环境变化的重要调控系统已愈来愈受关注,关于PhoPR TCS在MTB的致病机制调控方面的研究正在成为新的热点。

Two-component signal transduction system （TCS） exists extensively in prokaryotic cell, which plays a key role of regulation in the growth, differentiation, metabolism, virulence, persistence, and pathogenicity. PhoPR two-component signal transduction system, as one of two-component systems, is the most basic and the most importantly sensitive to the envi- ronmental changes and makes corresponding certain reaction system adapt to changes in the host microenvironment. Therefore, PhoPR TCS which is an important regulatory system of Mycobacterium tuberculosis （MTB） to adapt to environmental change has been increasing concern, even PhoPR TCS is becoming the new front-burner issue in the pathogenesis of MTB regulation of research.