MicroRNA对药物转运体调控作用的研究进展

Development of microRNA-dependment control of drug transporter

MicroRNA作为一类单链非编码小分子RNA,通过与靶基因mRNA 3'端非编码区(3'-untranslated region,3'-UTR)的互补结合来调节靶基因的表达,在生物发育、细胞分化、增殖和凋亡中发挥重要作用,与人类多种疾病如恶性肿瘤、糖尿病等的发生发展密切相关。MicroRNA表达的变化可影响药物代谢酶和转运体的表达,进而影响药物效应。目前有关药物代谢酶的研究较为深入,而对转运体的研究则相对较少。本文通过总结近几年国内外相关研究,从MicroRNA的作用机制及其对药物转运体的调控作用方面进行综述,以期为指导临床个体化用药提供理论依据。

MicroRNA is a class of small noncoding single-stranded molecule RNA, regulating the expression of target genes though com- plementary binding with the target gene mRNA 3＇untranslated region （3＇-untranslated region, 3＇ UTR） and plays an important role in biology developmental, cell differentiation, proliferation and apoptosis. And it closely related to the occurrence and development with many human diseases such as cancer, diabetes and so on. Drugmetabolizing enzymes and transporters expression can be affected by the changes of MicroRNA expression, thereby affecting drug effect.Current researches on drug metabolizing enzymes are more in-depth, while the transporters are relatively small. This paper summarizes research at home and abroad in recent years, the mechanism of action about MicroRNA and its regulation about drug transporter were reviewed. So as to provide a theoretical basis to guide the clinical individualized medicine.