表观扩散系数预测非小细胞肺癌预后的初探

Preliminary study on predicting the prognosis of non-small-cell lung carcinoma(NSCLC)using apparent diffusion coefficient

目的探讨表观扩散系数(ADC值)对非小细胞肺癌预后的应用价值。方法对46例经手术病理证实的非小细胞肺癌患者行多b值扩散加权成像(DWI),计算肿瘤在不同b值时的ADC值,分析肿瘤标本的分子生物学预后因子(CEA,Ki67,p53,c-erbB2),将ADC值与肿瘤预后因子进行Spearman相关性分析。结果 b=300s/mm2时肺癌与腺癌组ADC值与Ki67存在一定的相关性(r值为-0.565;P≤0.05)。其余各组病理类型肺癌与预后因子之间均未见明显相关性。结论 ADC值与非小细胞肺癌预后因子之间存在一定的相关性,有望成为预测肺癌预后的有潜在价值的指标之一。

Objective To investigate the value of apparent diffusion coefficient （ADC） in predicting the prognosis of non- small-cell lung carcinom （NSCLC）. Methods Four-six patients with NSCLC conformed by histopathology were examined with diffusion weighting imaging （DWI）. ADCs were calculated on multiple b values imaging. Correlations between the ADCs and prognosis factors （CEA, Ki67, p53, c-erbB2） were analysed by Spearman rank correlation. Results As b val- ue was 300 s/mm^2 , the ADC of adenocarcinoma and lung cancer was correlated negatively with Ki67 as a multiplicaiton factor （MF） （ r =-0. 565, P≤0.05）. There was no significant statistical correlation between other MFs and lung cancer. Conclusion Preliminary results revealed the ADCs of lung cancer had some correlation with tumorous prognosis factors. ADC might be a valuable index to evaluate the prognosis of lung neoplasm in vivo.