摘要
目的:研究兔脊柱融合术后邻近椎间盘软骨终板组织结构和形态学改变。方法:54只体重相当的12月龄日本大耳兔随机等分为2组,一组为实验组,使用椎弓根螺钉和钢丝内固定的方法融合L 5/6节段,另一组作为对照组,仅做相同部位皮肤切口后缝合。分别于术后3、6、9mo每组取8只动物处死并取出L 2/3、L 4/5及L 6/7软骨终板进行HE染色及Markin评分。结果:融合术后3、6及9mo时实验组L 4/5、L 6/7(邻近节段)软骨终板Mankin评分较对照组高,差异有统计学意义(P<0.05)。实验组L 4/5(融合平面以上邻近节段)与L6/7(融合平面以下邻近节段)软骨终板Mankin评分6、9mo时较对照组高,差异有统计学意义(P<0.05)。结论:脊柱融合内固定术后邻近节段软骨终板较未融合固定者易发生退变,并且融合平面以上邻近节段较融合平面以下邻近节段更易发生退变。
Objective：To study the structure and morphous of the adjacent cartilage endplate in rabbits after spinal fusion. Methods：Totally 54 twelve-month old Japanese rabbits were randomly divided into two groups. Each group included 27 rabbits. One group was experimental group,another one was control group. L 5/6 of all the experimental rabbits was surgery fused using screws and steel. The control group model was incised only the skin. 8 rabbits of each group were killed at three,six and nine months. After death,L 2/3,L 4/5 and L 6/7 spines were harvested. All the exemplar hematoxylin and eosin stain were performed. Results：Markin score of adjacent segment （ L 4/5 and L 6/7 ） in experimental group were higher than that in control group （ P〈0 . 05 ） . The differences of Markin score between L 4/5（the adjacent segment above the fusion level）and L 6/7（the adjacent segment below the fusion level）in the experimental group were statistically significant at 6month and 9month after spinal fusion（P〈0. 05）. Conclusion：The cartilage endplate of adjacent segment were easier to degenerate after spinal fusion,and adjacent segment above the fusion level was easier to degenerate than that below the fusion level.
出处
《内蒙古医科大学学报》
2014年第4期297-301,共5页
Journal of Inner Mongolia Medical University
基金
内蒙古卫生厅2010年医疗卫生科研计划项目(2010044)
关键词
脊柱融合
邻近节段退变
软骨终板
spinal fusion
adjacent segment degeneration
cartilage endplate
