FPS-1306的合成研究

Synthesis of FPS-1306

以1,2,4-三-O-乙酰基-4-O-苄基-α/β-L艾杜糖醛酸甲酯为起始原料,经溴化、糖苷化、脱乙酰基和选择性乙酰化合成了甲基6-O-乙酰基-3-O-苄基-2-苄氧碳酰氨基-2-脱氧-4-O-(2-O-乙酰基-3-O-苄基-α-L-吡喃艾杜糖醛酸甲酯)-α-D-吡喃葡萄糖(FPS-1306),其中2个中间体为新化合物,结构经1H NMR、13C NMR和MS表征.

Methyl 6-O-acetyl-3-O-benzyl-2-benzyloxy carbonyl amino-4-O-（2-O-hydroxyl-3-O-benzyl-4-O-acetyl-α- L-idopyranosyluronate）-α-D-glueopyranoside （FPS-1306） is synthesized by using 1, 2, 4-tri-O-aeetyl-4-O-benzyl- α/β-L-idofuranuronate as starting material through four reactions including bromination, glycosylation, deacetylation and selective acetylation. Two intermediates are novel compounds and their structures are characterized by 1H NMR, 13C NMR and MS.