咪达唑仑鼻腔滴入控制小儿热性惊厥的探讨

Clinical study on treating children's febrile convulsion with midazolam nasal drip

目的探讨咪达唑仑鼻腔给药治疗小儿高热惊厥的有效性和安全性。方法选取小儿热性惊厥患儿42例,随机分为治疗组和对照组各21例。治疗组鼻腔内滴入咪达唑仑0.2 mg/kg,对照组给予地西泮0.3－0.5 mg/kg静脉缓慢推注。比较分析两组患儿的惊厥控制时间、有效率及安全性。结果治疗组和对照组有效率分别为85.7%和90.5%,组间比较差异无统计学意义（P〉0.05）;治疗组患儿从到达医院急诊科至惊厥控制所用时间为（6.2±1.6）min,对照组为（8.1±0.9）min,差异具有统计学意义（P〈0.05）。两组均未发现明显不良反应。结论咪达唑仑鼻腔滴入可以有效地控制小儿热性惊厥,且更方便快捷。

Objective To explore the efficacy and safety of midazolam nasal drip in the treatment of children＇s febrile convulsion. Methods 42 children who suffered from febrile convulsion were randomly divided into two groups（the treament group and the control group）. 0.2 mg/kg midazolam nasal drip was delivered to each member of the treament group, while 0.3 - 0.5 mg/kg diazepam was given to each member of the control group by intravenous injection. Compared and evaluated the control time, effective rate and safefy regarding treament of children＇s febrile convulsion with midazolam nasal drip. Results Effective rate of treament group was 85.7%, while the control group was 90.5%. These weren＇t significantly different from each other（P〈0.05）. The control time of the treament group was（6.2 ±1.6）min, while the control group was（8.10 ±0.9）min（P〈0.05）. Both groups showed no obvious adverse reacitons. Conclusion It is effective and convenient to treat children＇s febrile convulsion with midazolam nasal drip.