还原型谷胱甘肽在慢性阻塞性肺疾病急性加重期患者中的应用被引量：2

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摘要目的观察还原型谷胱甘肽对慢性阻塞性肺疾病(COPD)急性加重期患者临床治疗效果。方法将58例符合入选标准的COPD急性发作期患者随机均分为治疗组和对照组,治疗组患者除给予常规抗感染、祛痰等治疗外,加用注射用还原型谷胱甘肽2.4 g/d加入到0.9%氯化钠溶液250mL中静脉滴注,qd,连用10 d;对照组仅给予常规治疗。观察治疗前后2组患者动脉血气指标、肺功能指标的变化。结果治疗10 d后,2组患者动脉血氧分压(PaO2)均较治疗前有显著提高,动脉血二氧化碳分压(PaCO2)均较治疗前显著降低(P<0.05),且两组间PaO2、PaCO2改善情况比较,治疗组显著优于对照组,差异均有统计学意义(P<0.05)。结论还原型谷胱甘肽可预防COPD患者的急性发作并改善其症状,降低病死率,可作为慢性阻塞性肺疾病的基础用药。

作者段文华杨文华林艺禅

机构地区福建省中医药大学第五临床医学院(福建省三明市第二医院)

出处《中国处方药》 2014年第10期51-52,共2页 Journal of China Prescription Drug

关键词还原型谷胱甘肽慢性阻塞性肺疾病氧化-抗氧化失衡

分类号 R563.9 [医药卫生—呼吸系统]

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参考文献4

1王沁.N-乙酰半胱氨酸抗氧化作用在慢性阻塞性肺疾病治疗的进展[J].临床肺科杂志,2008,13(10):1313-1314. 被引量：18
2MacNee W. Oxidants/antioxidants and chronic obstructive pulmonarydisease: Pathogenesis to therapy. Novartis Found Syrup, 2001, 234: 169-185.
3Sethi S, Murphy TF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med, 2008:359 (22) : 2355-2365.
4Soriano JB, Agusfl A. The yin and yang of COPD: or balancing repair (yang) and inflammation (yin). Eur Respir J, 2008,32 (6) : 1426-1427.

二级参考文献11

1Pela R, Calcagni-AM, Subiaco S, et al. N-acetylcysteine reduce the exacerbation rate in patients with moderate to server COPD. Respirationg, 1999,66 ( 6 ) :495 - 500.
2GrunsvenPM. LongtermeffectsoflnhaledcorticostecoidsinCOPD: arnetaanalysis. Thoras, 1999,54:7 - 14.
3KasielskiM, NowakD. Longtermadministra tionofNacetylcystinedecreaseshydrogenperox ideexhalationinsubjectswithchronicobstruc tivepulmonarydisease. RespirMed,2001,95 :448 - 456.
4CrossCE. Acuteinvivoeffectsofrecombinanttumornecrosisfactor. Labinvest, 1994,102 (suppl10) : 185-191.
5Reichenberger F, Tarnm M, N-acetylcysteine in the therapy of chronic bronchitis, Pneumologie,2002,56 (12) :793 - 797.
6Kasielski M, Nowak D, Long-term administration of N - acetyleysteine decrease hydrogen peroxide exhalation in subject with chronic obstructive pulmononary disease. Respir Med,2001,95 (6) :448 -456
7Gerrits CM, Herings RM, Leufkens HG, et al. N-acetylcysteine reduce the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease. Eur Respir J,2003,21 (5) :795 - 798.
8Ernst P, Suissa S. N-acetylcysteine is unlikely to reduce hospitalization for chronic obstructive pulmonary diease. Eur Respir J,2003,22 (5):865.
9Decramer M, Dekhuijen PN,Troostres T, et al. The Bronchitis Randomized On NAC Cost-Utility Study ( BRONCUS ) : hypothesis and design Eur Respir J ,2001,17 (3) :329 - 336.
10李虹,刘新民.慢性阻塞性肺疾病发病学研究新进展[J].中国临床医生杂志,2004,32(1):6-8. 被引量：12