原发性高血压病CAS与HP感染的相关性研究

Correlation Study of Helicobacter Pylori Infection and Carotid Artery Atherosclerosis in Patients with Essential Hypertension

目的:通过观察原发性高血压病(EH)患者颈动脉内膜中层厚度(CAIMT)、幽门螺杆菌抗体(HP-IgG)、血脂、高敏C-反应蛋白(hs-CRP)及同型半胱氨酸(HCY)的结果,探讨EH患者颈动脉粥样硬化(CAS)与HP感染的相关性。方法:以150例EH患者为研究对象,检测CAIMT、血脂及血清HP-IgG、hs-CRP、HCY结果,CAIMT的测量采用彩色多普勒超声仪,HP-IgG检测采用胶体金法,据CAIMT和HP-IgG结果分组后进行统计学对比分析。结果:1150例EH患者中89例CAIMT>1.0 mm为内膜增厚,67例HP-IgG(+)为HP感染。HP感染CAIMT增厚者显著高于HP非感染者(P<0.05),CAIMT增厚HP感染者显著高于CAIMT非增厚者(P<0.05)。2EH组患者并发CAIMT增厚与HP感染具有显著相关性(r=0.787,P<0.01)。3HP感染者血清TG、TC、LDL-C、HCY和hs-CRP水平均显著高于HP非感染者(P<0.05),血清HDL-C水平显著低于HP非感染者(P<0.05)。结论:EH患者CAS与HP感染具有相关性,可能通过影响血脂代谢、炎性反应及HCY水平促进CAS发生发展,清除或预防HP感染可能是防治EH合并CAS的策略之一。

Objective：To observe the correlation between CAS and HP infection in patients with EH by examined the CAIMT and HP-IgG antibody and blood lipid and hs-CRP and HCY. Methods：150 EH patients were as the research object,and CAIMT and blood lipid and serum HP-IgG antibody and hs-CRP and HCY were examined;CAIMT was measured by color doppler ultrasound instrument;HP-IgG antibody detection by colloidal gold method;there was a statistical comparison analysis. Results：In 89 of 150 patients with EH had CAIMT〉 1. 0 mm as the intimal thickening,67 cases had HP-IgG antibody（ ＋） as HP infection. In HP infection group,CAIMT thickening was significantly higher than that of no HP infection group（P〈0. 05）,in thickening CAIMT group,HP infection was significantly higher than that of no thickening CAIMT group（P〈0. 05）. EH patients with complicated CAIMT thickening and HP infection,and there was significant correlation（r = 0. 787,P 0. 01）. in HP infection group,serum TG,TC and LDL-C and HCY and hs-CRP levels were significantly higher than that of no HP infection group（P〈0. 05）,serum HDL-C were significantly lower than that of no HP infection group（P〈0. 05）. Conclusion：There is a correlation between CAS and HP infection in patients with EH,the HP is possibly influencing the blood lipid metabolism and inflammatory reaction and HCY levels to promote development of CAS,so treatment or prevention of HP infection may be one of the strategies of prevention and treatment of EH with CAS.