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STAT3的生物学作用及其与脓毒症的关系研究进展 被引量：2

Research advances in biological function of STAT3 and the relationship between STAT3 and sepsis
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摘要 STAT3信号通路在细胞的增殖、分化、凋亡和血管生成等方面起着重要作用，进而在肿瘤的发生发展机制领域被广泛研究。然而，近年来发现，STAT3还具有调节炎症反应的作用，使得对炎症性疾病---脓毒症发病机制的研究取得了极大的进步。现对近年来STAT3在脓毒症发病机制方面的研究进展进行综述，以帮助人类找到防治脓毒症的新的思路和策略。 STAT3 signaling pathway plays an important role in multiple cellular functions such as cell proliferation , differentiation , apoptosis and angiogenesis , therefore its mechanism in developing tumor has been widely studied .In recent years, however, we found that STAT3 plays a role in the regulation of inflammatory reaction , which greatly improved the investigations of the pathogenesis of sepsis.In this review, the progresses of STAT3 in the pathogenesis of sepsis in recent year are reviewed , in order to help human to find new ideas and strategies for the prevention and control of sepsis .
作者 王晓丹 张玉想
机构地区 解放军第
出处 《中国急救医学》 CAS CSCD 北大核心 2014年第10期877-880,共4页 Chinese Journal of Critical Care Medicine
关键词 信号转导子和转录激活子3(STAT3) 脓毒症 白细胞介素-6(IL-6) TH17 STAT3 IL-6 TH17 Sepsis
分类号 R392.11 [医药卫生—免疫学]
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参考文献21

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二级参考文献6

共引文献9

同被引文献17

  • 1Lesur O, Roussy JF, Chagnon F, et al. Proven infection - related sepsis induces a differential stress response early after ICU admis- sion[J]. Crit Care, 2010, 14(4) : R151.
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  • 7Flierl MA, Rittirsch D, Weckbach S, et al. Disturbances of the hypo- thalamic -pituitary -adrenal axis and plasma electrolytes during experimental sepsis[J]. Ann Intensive Care, 2011, 1: 53.
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  • 9Stepkowski SM, Chen W, Ross JA, et al. STAT3 : an important regulator of multiple cytokine functions [ J ]. Transplantation, 2008, 85(10) : 1372 -1377.
  • 10Fuchs F, Damm J, Gerstberger R, et al. Activation of the in- flammatory transcription factor nuclear factor interleukin -6 dur- ing inflammatory and psychological stress in the brain[J]. J Neu- roinflammation, 2013, 10: 140.

引证文献2

二级引证文献3

中国急救医学
2014年 第10期

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