平均血小板体积对心源性脑梗死患者早期病情评估的意义

The significance of mean platelet volume in assessing the early severity condition in patients with cardiac cerebral embolism

目的：观察心源性脑梗死患者入院时平均血小板体积（ MPV）与病情严重程度间的关系，探讨MPV对心源性脑梗死患者早期病情评估的临床价值。方法将91例心源性脑梗死患者分为NIHSS评分＞15分组及≤15分组，比较两组的基本临床资料、MPV水平及其他临床检验结果（如白细胞、红细胞分布宽度、血小板等），并进一步行Logistic回归分析，同时将所有病例按OCSP分型，统计MPV在不同亚组间差异。结果 NIHSS评分＞15分组MPV水平较NIHSS评分≤15分组显著升高（P＜0．05）。 Logistic回归分析结果显示，MPV升高为NIHSS评分＞15分的独立危险因素。 TACI组较LACI组MPV水平显著升高（P＜0．05）。结论 MPV水平是评估心源性脑梗死患者早期病情严重程度的独立危险因素之一，且高MPV水平可能与导致脑梗死的心源性血栓形成有关。

Objective To study the relation between mean platelet volume （ MPV） and the severity condition in cardiac cerebral embolism patients when admitted to hospital , and to investigate the clinical value of MPV in these patients .Methods 91 patients were divided into the NIHSS 〉15 group and NIHSS≤15 group.The statistical differences of basic clinical data , MPV and other chemical examination results （such as WBC, RDW, PLT, et al） between the two groups were compared .Logistic regression analysis was used to identify the independence risk factor , and the statistical differences of MPV between the subgroups were compared according to OCSP classification .Results MPV was significantly higher in the NIHSS 〉15 group than that in NIHSS≤15 group （P〈0.05）.The Logistic regression analysis showed that MPV was the independent risk factor to the NIHSS 〉15 group.MPV was significantly increased in the TACI group than LACI group （ P 〈0 .05 ） .Conclusion MPV is an independent risk factor to assess the severity condition in cardiac cerebral embolism patients in the early stage , and we suppose that higher MPV may lead to cardiac thrombosis related to cerebral embolism .