促红细胞生成素对难愈创面患者康复的影响

The effects of erythropoietin on impaired wound healing

目的 探讨促红细胞生成素（erythropoietin,EPO）水平对难愈创面康复的影响.方法 收集2011年9月～2012年12月治疗的60例超过两个月创面未愈合的患者,按随机方法分为EPO治疗组30例和常规治疗组（对照组）30例.治疗8周后比较两组患者创面肉芽组织和上皮的生长情况,并分别采用ELISA技术检测血清中EPO和血管内皮生长因子（VEGF）水平.结果 与对照组同期比较,EPO治疗2～8周患者创面肉芽组织生长情况和上皮化程度均显著增加（P＜0.05）,同时血清EPO含量和VEGF水平均显著高于对照组（P＜0.05）.结论 促红细胞生成素可促进难愈创面肉芽组织的生长、血管的再生和患者创面的愈合.

Objective To investigate the effect of erythropoietin （EPO） on impaired wound healing.Methods 60 patients with impaired wound more than two months were randomly divided into EPO treatment group （n=30） and rou tine treatment group （control group,n=30）.The growth of wound granulation tissue and epithelial in both group were measured and compared 8 weeks after treatment.The level of EPO and vascular endothelial growth factor （VEGF） in serum were detected by enzyme-linked immuno sorbent assay.Results Compared with control group,the growth of wound granulation tissue and epithelial of patients in EPO treatment group increased significantly in the same period （P〈0.05）,meanwhile levels of EPO and VEGF in serum were significantly higher than that of control group （P〈0.05）.Conclusion Erythropoietin can promote the growth of wound granulation tissue,regeneration of blood vessels and promote wound healing.